FIELD: chemistry.
SUBSTANCE: invention relates to bifunctional compounds. In particular, the invention relates to compounds which contain, at one end, a VHL ligand attached to ubiquitin ligase, and at the other end, a group that binds the target protein, so that the target protein is placed in close proximity to the ubiquitin ligase to effect degradation (and inhibition) of this protein, exhibits a wide range of pharmacological activity associated with compounds according to the present invention, associated with degradation / inhibition of target polypeptides.
EFFECT: inventions can be used as modulators of target ubiquitination, especially inhibitors of different polypeptides and other proteins that are degraded and / or otherwise inhibited by bifunctional compounds in accordance with the present invention.
32 cl, 19 dwg, 2 tbl, 1 ex
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