FIELD: biotechnology.
SUBSTANCE: invention relates to bifunctional compounds represented by a chemical structure: PTM-L-ULM, where PTM is a small molecule of a protein-targeting fragment, which binds to intracellular target protein selected from a group consisting of focal adhesion kinase, tyrosine kinase, estrogen receptor, androgen receptor, BET protein containing bromodomain, Ras, Raf, and epidermal growth factor receptor; L is a chemical linker group binding ULM to PTM; and ULM is a small molecule of a binding fragment of ubiquitin ligase E3 Von Hippel Lindau (VHL).
EFFECT: obtaining compounds enhancing the degradation of target proteins.
16 cl, 19 dwg, 2 tbl, 1 ex
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