1,3,4-OXADISOLAMIDE DERIVATIVE COMPOUND AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF Russian patent published in 2019 - IPC C07D271/10 C07D413/10 C07D413/12 A61K31/4245 

FIELD: chemistry.

SUBSTANCE: invention relates to 1,3,4-oxadiazolamide derivative represented by following formula I, stereoisomer or pharmaceutically acceptable salt thereof, where L₁, L₂ or L₃ each independently represent a bond or -(C₁-C₂ alkylene)-; Z₁ - Z₄ each independently represent N or CR^Z, where three or four of Z₁ - Z₄ each independently represents CR^Z, and R^Z is -H or -X; R₁ is -CX₂H or -CX₃; R₂ is -(C₁-C₄ alkyl), -(C₃-C₆ cycloalkyl), -phenyl, pyridinyl, or . Y is -N-, -O- or -S(=O)₂-, when Y is -N-, R₄ and R₈ each independently represent -H, -(C₁-C₄ alkyl), -C(=O)-(C₁-C₄ alkyl), -C(=O)-(C₃-C₆ cycloalkyl), -C(=O)-O(C₁-C₄ alkyl), -C(=O)-CF₃, -S(=O)₂-(C₁-C₄ alkyl), -oxetanyl or benzyl, and when Y is -O- or -S(=O)₂-, R₄ and R₈ are absent; R₅ -R₈ each independently represent -H, - (C₁-C₄ alkyl), -OH, -CH₂OH or -C(=O)-NH₂, and a - c each independently represent an integer having value of 1 or 2; R₃ is phenyl, -phenyl, which can be substituted with -X, and X is F, Cl, Br or I.

(I).

EFFECT: compounds of the invention are intended for preparing a drug for treating histone deacetylase of 6-mediated disease.

10 cl, 2 tbl, 101 ex