USE OF 3,3'-(1,4-PHENYLENE)BIS[2-ARYL-2-AZASPIRO[3.5]NONAN-1-ONES] AS AGENTS WITH ANALGESIC ACTIVITY Russian patent published in 2023 - IPC C07D403/10 A61K31/397 A61P29/00 

Abstract RU 2808986 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to the use of compounds of the class of 2-azaspiro[3.5]nonan-1-ones, in particular 3,3'-(1,4-phenylene)bis[2-aryl-2-azaspiro[3.5]-nonan-1-ones ], where Ar=4-CH3OS6H4 (a), Ar=Ph (b), Ar=3-ClC6H4 (c), Ar=2.5-(CH3)2C6H4 (d), as agents with antinociceptive activity.

EFFECT: use of 3.3'-(1,4-phenylene)bis[3-aryl-2-azaspiro[3.5]-nonan-1-ones], exhibiting high analgesic activity at a concentration of 50 mg/kg.

1 cl, 1 tbl, 5 ex

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RU 2 808 986 C1

Authors

Uchuskin Maksim Grigorevich

Mendogralo Elena Iurevna

Makarov Anton Sergeevich

Nikiforova Elena Aleksandrovna

Rubtsov Aleksandr Evgenevich

Zverev Dmitrii Pavlovich

Makhmudov Ramiz Ragibovich

Dates

2023-12-05Published

2023-03-23Filed