FIELD: chemistry.
SUBSTANCE: group of inventions relates to the field of organic chemistry and specifically to 3-(2-aryl-2,4-dihydroxy-1-(2-hydroxyethyl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)quinoxaline-2(1H)-ones of general formula
, where Ar = Ph (a), 4-CH3C6H4 (b). Also described is a method for production thereof, which is carried out by reacting corresponding 8-aroyl-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-1,6,7-trions with o-phenylenediamine in a solvent medium with subsequent separation of desired products.
EFFECT: obtaining novel compounds which can be used both as initial products for synthesis of novel heterocyclic systems and in pharmacology as having analgesic activity.
4 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 9-AROYL-8-HYDROXY-6-(2-HYDROXYETHYL)-1,3,6-TRIAZASPIRO[4,4]NON-8-ENE-2,4,7-TRIONS, HAVING ANALGESIC ACTIVITY, AND A METHOD FOR PRODUCTION THEREOF |
2019 |
- Tretyakov Nikita Alekseevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
- Maslivets Anna Andreevna
|
RU2707197C1 |
| APPLICATION OF 3-(2,4-DIHYDROXY-1-(2-HYDROXYPROPYL)-5-OXO-2-(4-CHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROL-3-YL)QUINOXALIN-2(1H)-ONE AS AN AGENT WITH ANTIMICROBIAL ACTIVITY AGAINST CULTURES OF S. AUREUS AND C. ALBICANS |
2023 |
- Tretiakov Nikita Alekseevich
- Maslivets Andrei Nikolaevich
- Balandina Svetlana Iurevna
|
RU2806037C1 |
| 2-((3-(4-BROMOBENZOYL)-4-HYDROXY-1-(2-HYDROXYETHYL)-5-OXO-2,5-DIHYDRO-1H-PYRROL-2-YL)THIO) ACETIC ACID WITH ANALGESIC ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
- Tretyakov Nikita Alekseevich
- Makhmudov Ramiz Ragibovich
|
RU2763737C1 |
| APPLICATION OF 3'-AROYL-4'-HYDROXY-1'-(2-HYDROXYETHYL)SPIRO[BENZO[b][1,4]THIAZINE-2,2'-PYRROLE]-3,5'(1'H,4 H)-DIONES AS AGENTS WITH ANALGESIC ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
- Tretyakov Nikita Alekseevich
- Makhmudov Ramiz Ragibovich
|
RU2775547C1 |
| APPLICATION OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYALKYL)-1,3-DIALKYL-2-THIOXO-1,3,6-TRIAZASPIRO[4.4 NON-8-ENE-4,7-DIONES AS AGENTS WITH ANTIMICROBIAL ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
- Tretyakov Nikita Alekseevich
- Balandina Svetlana Yurevna
|
RU2763731C1 |
| APPLICATION OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYALKYL)-2-IMINO-1-THIA-3,6-DIAZASPIRO[4,4]NON-8-EN-4,7-DIONES AS AGENTS, WITH ANTIMICROBIAL ACTIVITY |
2022 |
- Maslivets Andrei Nikolaevich
- Tretiakov Nikita Alekseevich
- Balandina Svetlana Iurevna
|
RU2790479C1 |
| USE OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYETHYL)-1,3,6-TRIAZASPIRO[4,4]NON-8-EN-2,4,7-TRIONES AS ANTITUBERCULOUS AGENTS |
2023 |
- Maslivets Andrei Nikolaevich
- Tretiakov Nikita Alekseevich
- Balandina Svetlana Iurevna
|
RU2798423C1 |
| 3'-AROYL-1-BENZYL-4'-HYDROXY-1'-(2-HYDROXYETHYL)-6,6-DIMETHYL-6,7-DIHYDROSPIRO[INDOLO-3,2'-PYRROLE]-2,4,5'(1H,1'H,5H)-TRIONES POSSESSING ANALGESIC ACTIVITY AND A METHOD FOR THEIR PREPARATION |
2018 |
- Tretyakov Nikita Alekseevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
- Galeev Andrej Ruslanovich
|
RU2688931C1 |
| THE USE OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYALKYL)-2-THIOXO-1,3,6-TRIAZASPIRO[4.4]NON-8-EN-4,7-DIONES AS AGENTS WITH ANTIMICROBIAL ACTIVITY AGAINST S. AUREUS |
2022 |
- Maslivets Andrei Nikolaevich
- Tretiakov Nikita Alekseevich
- Balandina Svetlana Iurevna
|
RU2790379C1 |
| APPLICATION OF 1-BENZYL-4'-HYDROXY-1'-(2-HYDROXYETHYL)-3'- (METHOXYBENZOYL)-6,6-DIMETHYL-6,7-DIHYDROSPIRO[INDOLE-3,2'-PYRROLE] 2,4 ,5'(1H,1'H,5H)-TRIONE AS AN AGENT WITH ANTIHYPOXIC ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
- Tretyakov Nikita Alekseevich
- Makhmudov Ramiz Ragibovich
|
RU2763738C1 |
