SOLID PHARMACEUTICAL PREPARATION, METHOD OF ITS PREPARATION AND USE Russian patent published in 2023 - IPC A61K9/14 A61K9/20 A61K9/48 A61K31/46 A61P25/30 A61P25/20 A61P25/22 A61P11/00 

FIELD: medicine.

SUBSTANCE: group of inventions discloses a solid pharmaceutical composition for the treatment of a disease associated with orexin, wherein the said solid pharmaceutical composition contains an active ingredient, wherein the said active ingredient is a compound of formula (II) or a pharmaceutically acceptable salt thereof or a mixture thereof; and the D90 particle size of the active ingredient is 35 μm or less. The group of inventions also discloses a method of production of a tablet, a dosage form for treating an orexin-related disease and a method of treating an orexin-related disease.

EFFECT: ensuring good stability, good solubility and high bioavailability of a solid pharmaceutical composition containing a compound of formula (II).

20 cl, 10 dwg, 10 tbl, 21 ex