COMPOSITIONS AND METHODS OF STEM CELL TRANSPLANTATION Russian patent published in 2023 - IPC C12N5/789 C12N15/63 A61K35/28 C12N5/78 C12N9/22 C12N15/85 

Abstract RU 2809803 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a method of obtaining a genetically modified population of cells enriched in CD34 containing a polynucleotide sequence encoding a polypeptide of the Fanconi anemia complementation group (FANC), or a functional variant or a fragment thereof functionally related to a promoter sequence active in eukaryotes, and CD34+ cells with a purity of <30%.

EFFECT: invention is effective for treating Fanconi anemia in a subject.

22 cl, 1 dwg, 3 tbl, 4 ex

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RU 2 809 803 C2

Authors

Beard, Brian

Sevilla Navarro, Julian

Shah, Gaurav

Patel, Kinnari

Prabhakar, Raj

Dates

2023-12-19Published

2019-04-11Filed