FIELD: pharmaceutical industry.
SUBSTANCE: group of inventions relates to a method of producing a depigmented allergen extract, to a composition, and a vaccine based on it. A method of producing a depigmented allergen extract, comprising the following: a) alkalizing the native allergen extract to a pH of 7 to 11 from 1 minute to 24 hours; then b) subjecting the said extract to a first molecular fraction removal step to remove molecules smaller than 3.5 kDa; and c) adjusting the pH to neutral to obtain a depigmented allergen extract. Depigmented allergen extract for the treatment of allergies. Depigmented polymerized allergen extract for the treatment of allergies. Pharmaceutical composition for the treatment of allergies, containing an allergen extract. A vaccine for the treatment of allergies containing an allergen extract.
EFFECT: depigmented allergen extract obtained by the method described above is characterized by an increased allergen content and increased biological activity.
17 cl, 29 dwg, 9 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING ALLERGEN EXTRACT | 2011 |
|
RU2572230C2 |
| METHOD OF PRODUCING ALLERGEN EXTRACT | 2011 |
|
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| HYBRID PEPTIDE CARRYING PROTEINS AS VACCINES AGAINST ALLERGY | 2012 |
|
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| DNA SEQUENCE AND PRODUCTION OF GRASS POLLEN ALLERGEN Phi p4 USING RECONBINANT METHODS | 2003 |
|
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| MODIFICATION OF GROUP 6 POACEAE (BLUEGRASS) ALLERGENS WITH LOW ALLERGENIC CAPACITY DUE TO MUTAGENESIS OF PROLINE RESIDUES | 2010 |
|
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| MICROPARTICLES CONTAINING CARBOHYDRATE SPHERES COVALENTLY BONDED WITH ALLERGEN | 2003 |
|
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| ALLERGEN-CONTAINING DOSAGE FORM | 2003 |
|
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| VERSIONS OF GROUP OF 5 ALLERGENS OF TRUE GRASSES WITH REDUCED ALLERGENICITY RESULTING FROM MUTAGENESIS OF PROLINE RESIDUES | 2010 |
|
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| ALLERGOIDS PREPARED OF ALLERGENS | 2009 |
|
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| VARIANTS OF GROUP 5 ALLERGENS OF CEREALS WITH REDUCED ALLERGENICITY DUE TO MUTAGENESIS OF PROLINE RESIDUES | 2010 |
|
RU2658767C1 |
