METHOD OF DIFFERENTIAL DIAGNOSIS OF PAROXYSMAL SYMPATHETIC HYPERACTIVITY SYNDROME IN PATIENTS WITH SEVERE BRAIN DAMAGE OF VARIOUS ETIOLOGIES Russian patent published in 2023 - IPC A61B5/205 A61B5/01 A61B5/22 G01N33/68 

FIELD: medicine; intensive care.

SUBSTANCE: invention can be used for the differential diagnosis of paroxysmal sympathetic hyperactivity syndrome (PSHA) in patients with severe brain damage of various etiologies. The following is measured: heart rates, blood pressure, respiratory rates, Kerdo index is calculated, body temperature is measured axillary and rectally, the frequency of episodes of autonomic instability in 24 hours is determined, hyperhidrosis, hyperemia and greasiness of the skin, the level of albumin in the blood plasma are also determined, the increase in muscle tone according to the Ashworth scale is assessed. The results are assigned points on a scale of severity of PSGA syndrome criteria, in accordance with Table 1 presented in the description. If the score is 0, there is no evidence of PSGA syndrome; if the score is 1–10 there is mild PSGA syndrome; if the score is 11–20 there is moderate PSGA syndrome; if the score is 21–30 there is severe PSGA syndrome. If the score exceeds 10, the level of procalcitonin in the blood plasma is determined, the pain syndrome and its severity are assessed using a 5-point verbal pain rating scale, heart rate, blood pressure and axillary and rectal body temperature are measured, the difference between rectal and axillary body temperature is determined. The results obtained are assigned points in accordance with Table 2 presented in the description. If the total score is 0, there is no data for conditions other than PSGA syndrome; at the score of 1–5 there may be a combination of PSGA syndrome with other conditions requiring additional diagnostics and treatment; at the score of 6–11 PSGA syndrome is doubtful; at the score of 12–18 PSGA syndrome is excluded. If the total score is less than 10 for the indicators obtained in accordance with Table 1, the characteristics are assessed in accordance with Table 1 and Table 2, over time.

EFFECT: method allows to increase the accuracy of differential diagnosis of paroxysmal sympathetic hyperactivity syndrome by assessing the totality of the most significant indicators.

1 cl, 2 tbl, 2 ex