METHOD OF PREVENTING GASTROINTESTINAL BLEEDING FROM THE UPPER GASTROINTESTINAL TRACT IN PATIENTS WITH SEVERE BRAIN DAMAGE OF VARIOUS ETIOLOGIES Russian patent published in 2023 - IPC A61F7/00 A61K31/4168 A61K31/4468 A61K31/515 A61P1/04 

FIELD: medicine, intensive care.

SUBSTANCE: invention can be used to prevent gastrointestinal bleeding in neurological and neurosurgical patients with severe brain damage of various etiologies. In combination with conservative therapy, including the administration of proton pump inhibitors (PPIs) — omeprazole 40 mg 2 times a day, an additional microfluidic opioid analgesic — fentanyl is intravenously administered at a dose of 1 μg/kg/h, besides a patient is intravenously administered alpha-2 adrenoagonist — clonidine at a dose of 0.8 mcg/kg/h and hypnotic — sodium thiopental at a dose of 4 mg/kg/h for 24–72 hours. When the patient's condition stabilizes, the medicinal products are canceled in the following sequence: hypnotic, opioid analgesic, alpha-2 adrenoagonist.

EFFECT: invention improves the efficiency of preventing gastrointestinal bleeding from the upper gastrointestinal tract in patients with severe brain damage of various etiologies.

1 cl, 1 tbl, 2 ex