FIELD: organic chemistry and pharmaceuticals.
SUBSTANCE: group of inventions relates to compounds useful for inhibiting general amino acid regulating kinase 2 with constant repression (GCN2). The following is disclosed: a compound of one of the formulas XV-a, XV-b or XV-c or a pharmaceutically acceptable salt thereof, where the meanings of the radicals R1, R are as presented in claim 1. In addition, a specific compound selected from the group, a pharmaceutical composition having a general amino acid regulatory kinase 2 (GCN2) inhibitory activity based on the disclosed compounds, is disclosed, and in addition, the use of these compounds or a pharmaceutical composition for inhibiting GCN2 in a biological sample and for obtaining a medicinal product for treating a GCN2-mediated disorder, disease or condition in a patient.
EFFECT: group of inventions provides effective inhibition of GCN2.
39 cl, 6 tbl, 26 ex
| Title | Year | Author | Number |
|---|---|---|---|
| GCN2 INHIBITORS AND THEIR USE | 2019 |
|
RU2811408C2 |
| NEW COMPOUNDS AND COMPOSITIONS FOR NAMPT INHIBITION | 2011 |
|
RU2617988C2 |
| FIVE-MEMBERED HETEROCYCLIC PYRIDINE COMPOUNDS AND PREPARATION METHOD AND USE THEREOF | 2014 |
|
RU2668074C2 |
| CONDENSED DERIVATIVES OF IMIDAZOLE AND PYRAZOLE AS MODULATORS OF ACTIVITY TNF | 2014 |
|
RU2686117C1 |
| HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | 2018 |
|
RU2797822C2 |
| AZADECALINS CONDENSED WITH HETEROARYLKETONES - GLUCOCORTICOID RECEPTOR MODULATORS | 2013 |
|
RU2639867C2 |
| THIAZOLINO-2-PYRIDONES WITH CONDENSED RINGS IN COMBINATION WITH A DRUG AGAINST TUBERCULOSIS | 2018 |
|
RU2791467C2 |
| CYCLIC CYANOENONE DERIVATIVES AS KEAP1 MODULATORS | 2021 |
|
RU2822828C1 |
| 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES | 2020 |
|
RU2822388C2 |
| SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | 2019 |
|
RU2812726C2 |
