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(19)

(11)

2 686 117

(13)

(51)

IPC

C07D235/04(2006-01-01)

C07D231/56(2006-01-01)

A61K31/4184(2006-01-01)

A61K31/416(2006-01-01)

A61P3/00(2006-01-01)

A61P9/00(2006-01-01)

A61P25/00(2006-01-01)

A61P25/28(2006-01-01)

A61P27/02(2006-01-01)

A61P29/00(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2016126658, 2014-12-08

(24)

Start date

2014-12-08

(22)

Actual filing date

2014-12-08

(45)

Published

2019-04-24

(72)

Inventor

Braun Dzhulien AlisterKalmiano Mark DanielDzhouns Elizabet PerlKroplin BorisRyuberson Dzhejms TomasSelbi Mattyu DankanSho Majkl AlanChzhu Chzhaonin

(73)

Holder

Ucb Biopharma Sprl

CONDENSED DERIVATIVES OF IMIDAZOLE AND PYRAZOLE AS MODULATORS OF ACTIVITY TNF Russian patent published in 2019 - IPC C07D235/04 C07D231/56 A61K31/4184 A61K31/416 A61P3/00 A61P9/00 A61P25/00 A61P25/28 A61P27/02 A61P29/00 A61P37/00

Abstract RU 2686117 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to substituted benzimidazole derivatives, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine and analogues thereof, which are active modulators of TNFα activity person.

EFFECT: disclosed compounds are useful for treating and / or preventing various human diseases, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ophthalmic disorders and oncological disorders.

7 cl, 5 tbl, 53 ex

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RU 2 686 117 C1

Authors

Braun Dzhulien Alister

Kalmiano Mark Daniel

Dzhouns Elizabet Perl

Kroplin Boris

Ryuberson Dzhejms Tomas

Selbi Mattyu Dankan

Sho Majkl Alan

Chzhu Chzhaonin

Dates

2019-04-24—Published

2014-12-08—Filed