HETEROCYCLIC DERIVATIVE WITH AROMATIC 5-MEMBER CYCLE POSSESSING NPY Y5 RECEPTOR ANTAGONIST ACTIVITY Russian patent published in 2016 - IPC C07D271/06 C07D413/04 A61K31/4245 A61K31/4439 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or its pharmaceutically acceptable salt, where R¹ is an unsubstituted C_1-4 alkyl or substituted with 1 methyl or unsubstituted C₃ cycloalkyl, p represents 1, q and r represent 0, where the group of formula -(A)-R² represents 1,2,4-oxadiazolyl substituted with radical R² in the third position of the ring, and R² is a substituted with one or more substitutes selected from fluorophenyl, phenyl or F, or unsubstituted C_1-4 alkyl; substituted with one or more substitutes selected from methyl, F, CF₃ or phenyl, or unsubstituted C_3-5 cycloalkyl; substituted with one or more substitutes selected from F, Cl, trifluoromethyl or trifluoromethoxy, or unsubstituted phenyl; substituted with one substitute selected from F or trifluoromethyl, pyridyl. Invention also relates to a compound of formula (IV) or its pharmaceutically acceptable salt, where R¹ is an unsubstituted C_1-4 alkyl, where the group of formula -(B)-R² represents 1,2,4-oxadiazolyl substituted with radical R² in the third position of the ring, and R² represents an unsubstituted galoC_1-4 alkyl. Compounds of formulae (I) and (IV) are intended for preparing a pharmaceutical composition possessing NPY Y5 receptor antagonist activity, containing an effective amount of the compound or its pharmaceutically acceptable salt and a carrier.

EFFECT: heterocyclic derivatives with a 5-member aromatic cycle possessing NPY Y5 receptor antagonist activity.

9 cl, 38 tbl