METHOD FOR PRODUCING 2-(METHYLTHIO)-4-(4-NITROPHENYL)-6-ETHYL-1,3,5-TRIAZINE Russian patent published in 2022 - IPC C07D251/22 A61P31/00 

Abstract RU 2765005 C1

FIELD: medicine.

SUBSTANCE: invention relates to a method for producing 2-(methylthio)-4-(4-nitrophenyl)-6-ethyl-1,3,5-triazine of the formula I that can be used as an antimicrobial agent. The method is carried out by recycling 4-hydroxy-5-methyl-2-(4-nitrophenyl)-6H-1,3-oxazine-6-one with 1,3-binucleophile-S-methylisothiourea, in a molar ratio of 1:2 in a methanol medium at 64°C during 4 h with subsequent release of the target product from the reaction mass by distilling the solvent and further treatment of solid residue with a sodium bicarbonate solution.

EFFECT: obtaining 2-(methylthio)-4-(4-nitrophenyl)-6-ethyl-1,3,5-triazine for use as an antimicrobial agent in medicine.

1 cl, 4 tbl, 2 ex

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RU 2 765 005 C1

Authors

Kolesnik Denis Andreevich

Kuvaeva Elena Vladimirovna

Yakovlev Igor Pavlovich

Strelova Olga Yurevna

Semakova Tamara Leonidovna

Ksenofontova Galina Vladimirovna

Dates

2022-01-24Published

2020-11-30Filed