LIQUID COMPOSITION CONTAINING ANTIBODY TO HUMAN INTERLEUKIN-4 RECEPTOR ALPHA Russian patent published in 2024 - IPC A61K39/395 A61K47/02 A61K47/22 A61K47/26 A61K9/08 A61P29/00 A61P37/08 

FIELD: pharmaceuticals; medicine.

SUBSTANCE: 1st object is a liquid composition for preventing, treating or reducing the intensity of inflammation or an allergic disease, containing an antibody to human interleukin-4 receptor alpha at a concentration of 100–165 mg/ml, a histidine hydrochloride buffer at a concentration of 5–10 mmol/ l, a protective agent, which is a combination of trehalose at a concentration of 60–150 mmol/l and sodium chloride at a concentration of 80–120 mmol/l, and the surfactant Tween 80 at a concentration of 0.01–0.2%, with a pH is 6.0–6.4. 2nd object is the use of a liquid composition to obtain a medicinal product for the treatment of inflammation or an allergic disease. 3rd and 4th objects are a container containing a liquid composition and kit for preventing, treating or reducing the intensity of inflammation or an allergic disease. 5th object is a method of preventing, treating or reducing the intensity of inflammation or an allergic disease, including the administration of a liquid composition.

EFFECT: provision of a stable liquid composition containing the antibody in high concentration.

24 cl, 19 dwg, 16 tbl, 8 ex