FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to the use of Lysylendopeptidase Lys-C from Lysobacter enzymogenes in the processing of botulinum neurotoxin of serotype F (BoNT/F).
EFFECT: use of Lys-C for proteolytic splitting of single-stranded BoNT/F enables to obtain an active double-stranded BoNT/F.
9 cl, 11 dwg, 2 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHODS FOR PRODUCING PROTEOLYTICALLY PROCESSED POLYPEPTIDES | 2019 |
|
RU2727402C1 |
| HYBRID NEUROTOXINS | 2017 |
|
RU2782382C2 |
| ENGINEERED BOTULINUM NEUROTOXIN | 2016 |
|
RU2746736C2 |
| CONSTRUCTED BOTULINUM NEUROTOXIN | 2017 |
|
RU2789302C2 |
| THERAPEUTIC AND COSMETIC USE OF SEROTYPE E NEUROTOXIN BOTULINUM | 2019 |
|
RU2800604C2 |
| BOTULINUM NEUROTOXIN BIOHYBRID | 2019 |
|
RU2816855C2 |
| COMPLEX, AGENT AND APPLICATION OF TYPE A BOTULINUM TOXIN CLOSTRIDIUM BOTULINUM | 2020 |
|
RU2783511C1 |
| SINGLE-DOMAIN ANTIBODY AND ITS MODIFICATIONS SPECIFICALLY BINDING TO BOTULINUM NEUROTOXIN TYPE A, AND METHOD OF USING THEM FOR THERAPY OR EMERGENCY PREVENTION OF INTOXICATION CAUSED BY BOTULINUM NEUROTOXIN TYPE A | 2021 |
|
RU2766348C1 |
| TETANUS TOXIN ANTIBODY AND USE THEREOF | 2020 |
|
RU2815280C1 |
| CD47-ANTIGEN-BINDING UNIT AND ITS USE | 2018 |
|
RU2780859C2 |
