METHOD OF PRODUCING DIPHENYLPHOSPHINYLACETIC ACID HYDRAZIDE Russian patent published in 2024 - IPC C07C241/04 C07C243/26 C07F9/53 A61K31/66 A61P25/00 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to a method of producing diphenylphosphinylacetic acid hydrazide (HDPAC), characterised by the fact that first diphenylphosphine oxide in a solvent selected from chloroform, methylene chloride or benzene is successively added with diisopropylethylamine, trimethylchlorosilane and chloro- or bromoacetic acid ester CHCH₂COOR, where R = –CH₃, –C₂H₅, X = –Cl, –Br, and the reaction is carried out to obtain diphenylphosphinylacetic acid ester, the reaction mass is washed with water, then hydrazine is added and stirred until a crystalline precipitate of HDPA is formed, evacuated to remove volatile components, the precipitate is separated and recrystallized.

EFFECT: provision of a simple method of producing HDPA with a high yield of the target product at lower energy costs.

3 cl, 4 ex