PHARMACEUTICAL COMPOSITION INCLUDING GABAPENTIN AND BENFOTIAMINE, DOSAGE FORM BASED ON IT, METHOD OF OBTAINING AND APPLYING SAID DOSAGE FORM Russian patent published in 2024 - IPC A61K9/22 A61K9/28 A61K31/197 A61K31/51 A61K47/02 A61K47/10 A61K47/38 A61J3/10 A61P3/02 A61P25/00 A61P29/00 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to a pharmaceutical composition, an oral solid dosage form that normalizes metabolic processes and has analgesic properties, to the methods of their preparation and use. A pharmaceutical composition that normalizes metabolic processes and has analgesic properties, comprising as active ingredients gabapentin from 200 mg to 700 mg and pharmaceutically acceptable ingredients that provide a modified release of gabapetin, and benfotiamine from 80 mg to 120 mg and pharmaceutically acceptable ingredients that provide a modified release of benfotiamine, and the amounts of active ingredients are indicated per dose. An oral solid dosage form that normalizes metabolic processes and has analgesic properties, including a pharmaceutical composition. A method of obtaining a dosage form, including preparing raw materials by sifting, includes the process of obtaining granules of each active substance, the tableting process, the process of applying a coating, the process of applying a second layer of film coating, in which benfotiamine is added to the mixture in an amount of not more than 20% of its total content in finished solid form. A method of producing an oral, solid dosage form made on the basis of a pharmaceutical composition, as the main active ingredients including gabapentin from 200 mg to 700 mg and pharmaceutically acceptable ingredients that provide a modified release of gabapetin, and benfotiamine from 80 mg to 120 mg and pharmaceutically acceptable ingredients, providing modified release of benfotiamine. The use of pharmaceutical compositions to reduce or stop neuropathic pain, to simultaneously influence the pathogenetic mechanisms of the formation of neuropathic pain, restore nerve function, replenish vitamin B1 deficiency, to normalize metabolic processes, for use as an analgesic.

EFFECT: above-described group of solutions makes it possible to simplify the schemes of influence of the claimed qualitative and quantitative composition of ingredients to reduce or stop neuropathic pain.

16 cl, 7 tbl, 4 ex