FIELD: medicine; traumatology; combustiology.
SUBSTANCE: invention can be used to simulate a long-term non-healing wound. In laboratory animals, hemodynamic disturbance is simulated by formation of chronic heart failure by daily 5-minute free swimming of the laboratory animal sequentially for 20 days with underlying intraperitoneal administration of 0.05 ml of 0.1% Mesatonum solution per each 100 g of laboratory animal weight. Further, 4 days before the experimental skin injury, severe drug hypothyroidism is induced by oral administration of propylthiouracil in dose of 1.0±0.2 mg per 100 g of laboratory animal weight once a day. Preparation is continued in this mode throughout the experiment. Skin is injured by applying a thermal burn to rats using a cylindrical steel applicator with a flat working part in the form of a circle with diameter of 20 mm. It is heated to constant temperature before exposure of the rat by immersing the applicator in boiling water for two minutes. Duration of application is 40 seconds.
EFFECT: method makes it possible to produce a model of a long-term non-healing wound, which is a conditional model of a comorbid patient, which can be used for further evaluation of regenerative properties of drugs.
1 cl, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NIOSOMAL ANTIMICROBIAL GEL FOR TREATING DIABETIC ULCERS, WOUNDS, BURNS, INCLUDING THOSE INFECTED WITH ANTIBIOTIC-RESISTANT MICROORGANISMS | 2021 |
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| DRUG FOR ACCELERATION OF THE HEALING OF THE PURULENT WOUNDS, CONTAINING CHLORIDE RUBIDIUM IN THE FORM OF SOLUTION | 2018 |
|
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| COMPOSITE FOR ACCELERATED HEALING OF WOUNDS OF VARIOUS AETIOLOGIES, USE OF COMPOSITE AS COSMETIC AGENT AND AS A THERAPEUTIC AGENT IN VETERINARY SCIENCE, AGENT FOR SKIN REGENERATION BASED ON COMPOSITE | 2017 |
|
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| WOUND-HEALING AND ANTIBACTERIAL AGENT | 2005 |
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| METHOD FOR TREATING BURNS OF DEGREE 3A BY APPLYING GLAUCONITE POWDER | 2020 |
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| METHOD OF OBTAINING MEDICATION, POSSESSING ANTIOXIDANT, CHOLAGOGIC, HEPATO RADIO- AND NEPHROPROTECTIVE, ANTIRADICAL, WOUND-HEALING ACTIVITY | 2007 |
|
RU2355412C1 |
| AGENT FOR THERAPY OF WOUND AND BURN SKIN LESIONS | 2018 |
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RU2687485C1 |
| MEANS FOR TREATING THERMAL BURNS | 2018 |
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RU2681944C1 |
| METHOD FOR SIMULATING LONG-TERM NON-HEALING WOUNDS TO ASSESS WOUND-HEALING ACTION OF BIOMEDICAL CELL PRODUCTS | 2018 |
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| METHOD OF OBTAINING BIOLOGICALLY ACTIVE SUBSTANCE FROM EMBRIONIC-EGG MASS FOR PREPARATION OF ANTI-BURN PLATE AND ANTI-FIRE PLATE ON ITS BASE | 2010 |
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RU2433171C1 |
