FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to embodiments of IgG-Fc polypeptides of domestic animals. Invention provides obtaining polypeptide IgG-Fc components having low binding affinity with C1q and CD16 and/or low antibody-dependent cell cytotoxicity (ADCC), as well as fused polypeptides based thereon with GLP-1 or glucagon, having increased half-life in blood serum.
EFFECT: invention can be used in veterinary science for treating diabetes, obesity and metabolic disease associated with diabetes or obesity.
61 cl, 7 dwg, 10 tbl, 17 ex
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