FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular to a polypeptide capable of reducing NGF signalling activity in a cell, comprising an extracellular domain (ECD) of a TrkA polypeptide (TrkA ECD) from a companion animal species, a linker (L) and a fusion partner, which is an Fc polypeptide (Fc), as well as a method for production thereof. Also disclosed are recovered nucleic acid coding said polypeptide, as well as a host cell containing it.
EFFECT: invention is effective for treating conditions induced by NGF, and for reducing activity of NGF signalling.
38 cl, 13 dwg, 18 tbl, 19 ex
| Title | Year | Author | Number |
|---|---|---|---|
| EMBODIMENTS OF IGG-Fc FOR USE IN VETERINARY SCIENCE | 2018 |
|
RU2814952C2 |
| POLYVALENT AND POLYSPECIFIC GITR-BINDING FUSED PROTEINS | 2016 |
|
RU2753439C2 |
| FUSED SERPINE POLYPEPTIDES AND METHODS OF THEIR APPLICATION | 2015 |
|
RU2746550C2 |
| FUSED SERPIN POLYPEPTIDES AND METHODS FOR USE THEREOF | 2019 |
|
RU2728861C1 |
| IL4/IL13 RECEPTOR MOLECULE FOR VETERINARY USE | 2018 |
|
RU2795591C2 |
| FUSED SERPIN POLYPEPTIDES AND METHODS FOR USE THEREOF | 2012 |
|
RU2698655C2 |
| IMMUNOCYTOKINES AND THEIR USE | 2021 |
|
RU2818371C1 |
| PROTEINS BINDING NKG2D, CD16 AND TUMOUR-ASSOCIATED ANTIGEN | 2018 |
|
RU2816716C2 |
| FUSED PROTEIN CONSTRUCTS FOR COMPLEMENT-RELATED DISEASE | 2019 |
|
RU2824402C2 |
| ANTIBODIES TO MYOSTATIN, POLYPEPTIDES CONTAINING FC-REGION VARIANTS, AND THEIR APPLICATION METHODS | 2016 |
|
RU2789884C2 |
