FIELD: biotechnology; chemistry.
SUBSTANCE: invention relates to biochemistry, in particular to a polypeptide specific for target tissue and comprising an antigen-binding domain and a transporting fragment, in which the transporting fragment has an inhibiting domain, inhibiting antigen-binding activity of an antigen-binding domain, in which the antigen-binding domain has a shorter half-life in blood than the transporting fragment. Disclosed is a pharmaceutical composition containing said polypeptide. Also disclosed is a method of producing said polypeptide.
EFFECT: invention enables to efficiently obtain said polypeptides.
14 cl, 23 tbl, 31 dwg, 16 ex
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