ADVANCED CORONAVIRUS VACCINE Russian patent published in 2024 - IPC A61K39/215 C07K14/05 

FIELD: biotechnology.

SUBSTANCE: immunogen containing a glycoengineered coronavirus spike protein containing a plurality of truncated N-glycans and one or more unmodified O-glycans is described, wherein the glycoengineered coronavirus spike protein consists of the amino acid sequence SEQ ID NO: 1 or a variant thereof having at least 96% identity with the amino acid sequence of SEQ ID NO: 1, or an immunologically active fragment thereof. The following is proposed: an immunogenic composition for inducing an immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or a variant thereof in a subject in need thereof, containing an effective amount of the immunogen described. The following is disclosed: a method of inducing an immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or a variant thereof in a subject in need thereof, comprising administering to the subject an effective amount of the proposed immunogenic composition.

EFFECT: invention provides improved immunogens, vaccines and methods of more effectively preventing and treating novel coronavirus infections.

20 cl, 13 dwg, 22 ex