METHOD FOR PREDICTION OF RISK OF TUMOUR PROGRESSION IN PATIENTS WITH OVARIAN CANCER Russian patent published in 2024 - IPC G01N33/52 G01N33/68 G01N33/574 G16H50/30 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, molecular biology and clinical laboratory diagnostics, and can be used for prediction of risk of tumour progression in patients with ovarian cancer. Before the beginning of the treatment, blood and ascitic fluid are examined, in which the number of atypical/hybrid Epcam+CD45+ cells is determined by flow cytometry. ELISA is used to determine the level of blood tumour markers CA125 and HE4. Obtained values are substituted into the formula for calculating the probability of developing tumour progression P. If P is more than 0.5459, a high risk is determined, and if P is less than or equal to 0.5459, a low risk of tumour progression is determined.

EFFECT: method provides higher accuracy and reduced invasiveness, possibility of predicting the clinical course of the disease before the treatment by determining the number of atypical/hybrid Epcam+CD45+ cells in the blood and ascitic fluid and the level of tumour markers CA125 and HE4 in the blood.

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