FIELD: biotechnology.
SUBSTANCE: invention relates to a humanized single-domain antibody to IL-4Rα, the method of its preparation, as well as the fusion protein and the medicinal product containing it. The following is also disclosed: a bispecific antibody for inhibiting cell proliferation induced by IL-5 protein or induced by IL-4Rα. The invention also relates to an isolated nucleic acid molecule encoding the above IL-4R antibodyα, as well as to the vector and cell containing it.
EFFECT: invention is effective for treating a disease induced by IL-4Rα.
11 cl, 9 dwg, 11 tbl, 12 ex
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