FIELD: pharmaceutics.
SUBSTANCE: present invention relates to pharmaceutical preparations. In a specific embodiment, the solid dispersion contains an active ingredient (R)-4-amino-1-(1-(but-2-ynyl)pyrrolidin-3-yl))-3-(4-(2,6-difluorophenoxy)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one or a salt thereof, and a carrier material, and the pH value is adjustable; application of method, according to which a corresponding amount of acid is added, which effectively inhibits the emulsification phenomenon in the process with a reverse solvent, thus obtaining a solid dispersion having an average particle size and uniform content.
EFFECT: disclosed is a solid dispersion and a method for production thereof.
6 cl, 2 dwg, 3 tbl, 6 ex
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