FIELD: chemistry; pharmaceutics.
SUBSTANCE: group of inventions relates to chemistry and pharmaceutics, specifically to a solid pharmaceutical composition for treating atopic dermatitis; to embodiments of its production method; as well as to embodiments of a method of treating atopic dermatitis, which involve administering to an animal in need thereof an effective amount of said solid pharmaceutical composition. Disclosed composition is a tablet and contains: a) a pharmaceutically effective amount of a compound of formula (I)
, dispersed in a polymer matrix, which is hydroxypropyl methylcellulose acetate succinate (HPMCAS), where the weight ratio of the polymer to the compound of formula (I) is from 10:1 to 5:1, wherein the compound of formula (I) is present in amorphous form; and b) a pharmaceutically acceptable carrier.
EFFECT: group of inventions provides higher bioavailability of the compound of formula (I).
29 cl, 3 dwg, 5 tbl, 5 ex
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Authors
Dates
2024-09-13—Published
2020-12-18—Filed