PHARMACEUTICAL COMPOSITION OF PYRAZOLE COMPOUND DISPERSED IN POLYMER MATRIX Russian patent published in 2024 - IPC A61K9/20 A61K31/4155 A61K47/38 A61P17/00 A61P17/04 

Abstract RU 2826604 C1

FIELD: chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to chemistry and pharmaceutics, specifically to a solid pharmaceutical composition for treating atopic dermatitis; to embodiments of its production method; as well as to embodiments of a method of treating atopic dermatitis, which involve administering to an animal in need thereof an effective amount of said solid pharmaceutical composition. Disclosed composition is a tablet and contains: a) a pharmaceutically effective amount of a compound of formula (I) , dispersed in a polymer matrix, which is hydroxypropyl methylcellulose acetate succinate (HPMCAS), where the weight ratio of the polymer to the compound of formula (I) is from 10:1 to 5:1, wherein the compound of formula (I) is present in amorphous form; and b) a pharmaceutically acceptable carrier.

EFFECT: group of inventions provides higher bioavailability of the compound of formula (I).

29 cl, 3 dwg, 5 tbl, 5 ex

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RU 2 826 604 C1

Authors

Kulczar, Christopher, D

Schenck, Luke, Ryan

Li, Yongjun

Rumondor, Alfred, C, F

Dates

2024-09-13Published

2020-12-18Filed