TMC 125 PREPARATION SPRAY DRYING PRODUCTION PROCESS Russian patent published in 2010 - IPC A61K31/505 A61K47/38 A61K47/30 A61K9/14 A61K9/20 A61J3/02 A61P31/18 

FIELD: medicine.

SUBSTANCE: present invention refers to a spray drying production process of a solid pharmaceutical powder containing microcrystalline cellulose in a solid dispersion of the anti-HIV compound etravirine (TMC125) in a water-soluble polymer. In a parent mixture, the relation of the water-soluble polymer to TMC 125 makes 10:1 to 1:1, and of microcrystalline cellulose to TMC 125 - 1:1 to 1:3. Said parent mixture of microcrystalline cellulose, a solution of the water-soluble polymer and etravirine is sprayed in the form of drops into a drying chamber by atomisers to form a solid dispersion of TMC 125 powder.

EFFECT: better solubility and bioavailability of the antiviral compound etravirine.

10 cl, 9 dwg, 2 tbl, 1 ex