FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular to a fusion protein – IL-6 antagonist. Said fusion protein contains a fragment of the extracellular domain of the IL-6R protein, represented by an amino acid sequence corresponding to positions 20–361 of SEQ ID NO: 1 with the substitution D358A, and the human IgG4 Fc fragment, attached to the IL-6R protein fragment from the C-terminus without a linker or by means of a linker sequence. Present invention also relates to an isolated nucleic acid molecule coding said fusion protein, an expression vector and a cell.
EFFECT: present invention provides a high degree of safety of therapeutic application of said protein and its potentially improved pharmacokinetic properties.
11 cl, 1 dwg, 2 ex
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| FUSED IMMUNOGLOBULIN PROTEINS | 2008 |
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