FIELD: biotechnology.
SUBSTANCE: present invention relates to recombinant fusion proteins—PDGFRα antagonists, consisting of a fragment of a soluble extracellular part of human PDGFRα protein and Fc-fragment human IgG4, connected by RS linker sequence. Also disclosed are nucleic acids coding said proteins, expression vectors containing said nucleic acids, and cells expressing said fused proteins.
EFFECT: obtained recombinant proteins are effective for blocking tyrosine kinase activity of PDGFR-pathways.
8 cl, 1 dwg, 1 ex
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