ANTI-BCMA ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND MEDICAL USE THEREOF Russian patent published in 2024 - IPC C07K16/28 C12N15/13 C12N15/62 A61K39/395 G01N33/53 C07K16/46 C12P21/08 C12N1/19 C12N1/21 C12N5/10 A61P35/00 A61P37/00 

Abstract RU 2819660 C2

FIELD: biotechnology.

SUBSTANCE: group of inventions relates to the field of immunology, in particular to the BCMA antibody, its antigen-binding fragment and their medical application. Disclosed are an anti-BCMA antibody or an antigen-binding fragment thereof, a pharmaceutical composition, a cytotoxic conjugate and use thereof as a medicinal agent for treating or detecting and diagnosing BCMA-mediated diseases or conditions. Antibody has high affinity, high specificity, low immunogenicity, high biological activity, significant anti-tumour action and enhanced endocytosis.

EFFECT: present invention can find further application in therapy of various BCMA-mediated diseases or conditions.

35 cl, 10 tbl, 9 ex

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RU 2 819 660 C2

Authors

Hua Haiqing

Bao Rudi

Dates

2024-05-22Published

2020-07-29Filed