FIELD: biotechnology.
SUBSTANCE: described is a group of inventions comprising a conjugate of an anti-B7-H4 antibody and a drug for transfer of a cytotoxic drug into cancer cells, method of producing an antibody conjugate, a pharmaceutical composition for treating a disease associated with human B7-H4, use of the conjugate of the antibody to B7-H4 or a pharmaceutical composition for preparing a drug for treating a disease associated with human B7-H4. In one of the embodiments, the conjugate is represented by the general formula
,
where D is a cytotoxic drug.
EFFECT: invention extends the range of products for treating diseases associated with human B7-H4.
18 cl, 4 dwg, 9 tbl, 15 ex
| Title |
Year |
Author |
Number |
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2020 |
|
RU2819660C2 |
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|
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|
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|
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|
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- Ren Wenming
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|
RU2830242C1 |
| ANTIBODY AGAINST B7-H3, ITS ANTIGEN-BINDING FRAGMENT AND THEIR MEDICAL USE |
2018 |
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|
RU2765306C2 |
| ANTIBODY TO CD40, ITS ANTIGENE-BINDING FRAGMENT AND ITS MEDICAL USE |
2018 |
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|
RU2779128C2 |
| ANTI-CD79B ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND PHARMACEUTICAL USE THEREOF |
2020 |
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|
RU2817143C2 |
