FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to stable liquid pharmaceutical formulations containing human parathyroid hormone. In various embodiments, the stable liquid pharmaceutical formulations contain human parathyroid hormone (huPTH), a buffer agent for maintaining the pH of the solution in range of 3 to 6, one or more stabilizing agents selected from a group consisting of sugars, salts, surfactants, proteins, chaotropic agents, fats and amino acids, a tonicity regulator, water and a preservative acceptable for parenteral administration.
EFFECT: said solution is sterile and ready for parenteral administration to a human patient.
1 cl, 43 dwg, 6 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR SYNTHESIS OF RECOMBINANT HUMAN PARATHYROID HORMONE | 2007 |
|
RU2441019C2 |
| PARATHYROID HORMONE ANALOGS AND USES THEREOF | 2011 |
|
RU2604809C2 |
| PHARMACEUTICAL COMPONENT BASED ON HUMAN PARATHYROID HORMONE AND INTRANASAL PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | 2001 |
|
RU2292219C2 |
| PHARMACEUTICAL FORMULATION CONTAINING BEVACIZUMAB | 2021 |
|
RU2819797C1 |
| STABLE AQUEOUS PEPTIDE PREPARATION, METHOD OF ITS PREPARING AND METHOD OF TREATMENT OF HORMONE-DEPENDENT DISEASE IN SUBJECT | 1997 |
|
RU2201248C2 |
| FORMULATIONS OF SINGLE DOMAIN ANTIGEN BINDING MOLECULES | 2013 |
|
RU2683861C2 |
| METHODS OF PULSING SYSTEMIC ADMINISTRATION OF PARATHYROID HORMONE ACTIVE FRAGMENT AND PHARMACEUTICAL COMPOSITIONS CONTAINING BIOLOGICALLY ACTIVE N-TERMINAL FRAGMENT OF PARATHYROID HORMONE | 1993 |
|
RU2142815C1 |
| COMPOSITIONS OF PARATHYROID HORMONE AND THEIR APPLICATION | 2008 |
|
RU2467762C2 |
| PHARMACEUTICAL COMPOSITIONS CONTAINING INSULIN | 2017 |
|
RU2758367C2 |
| STABLE PHARMACEUTICAL COMPOSITIONS, CONTAINING GAMMA AND ALPHA INTERFERONS IN SYNERGIC RATIO | 2006 |
|
RU2403057C2 |
