METHODS OF PULSING SYSTEMIC ADMINISTRATION OF PARATHYROID HORMONE ACTIVE FRAGMENT AND PHARMACEUTICAL COMPOSITIONS CONTAINING BIOLOGICALLY ACTIVE N-TERMINAL FRAGMENT OF PARATHYROID HORMONE Russian patent published in 1999 - IPC

FIELD: medicine, hormones. SUBSTANCE: invention relates to new methods of administration of parathyroid hormone and compositions of its biologically active fragment. The systemic delivery of parathyroid hormone in mammalian-host is performed by orally as a dispersion of N-terminal fragment of parathyroid hormone. This respiratory route of delivery of parathyroid hormone fragment provides the pulsing pattern of serum blood concentration of parathyroid hormone fragment. Compositions of parathyroid hormone fragment involve preparations of parathyroid hormone as dry powder, liquid solutions or suspensions able for spraying and aerosol propellents able for use in an inhaler as fixed doses. EFFECT: broadened arsenal of agents for administration of hormonal preparations in body. 21 cl, 2 dwg, 12 ex