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2 758 367

(13)

(51)

IPC

A61K38/28(2006-01-01)

A61P3/00(2006-01-01)

A61P43/00(2006-01-01)

A61K47/02(2006-01-01)

A61K47/10(2006-01-01)

(21) (22)

Application

2019118696, 2017-12-15

(24)

Start date

2017-12-15

(22)

Actual filing date

2017-12-15

(45)

Published

2021-10-28

(72)

Inventor

Norrman, MatiasKhostrup, SyuzannSteensgaard, Dorte, BerreShtrauss, Kholger, MartinKhansen, Roza, Rebekka, ErritseeKhavelund, SvennSklajn, MortenPedersen, Esper, Sennergord

(73)

Holder

Novo Nordisk A/S

PHARMACEUTICAL COMPOSITIONS CONTAINING INSULIN Russian patent published in 2021 - IPC A61K38/28 A61P3/00 A61P43/00 A61K47/02 A61K47/10

Abstract RU 2758367 C2

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to a pharmaceutical composition and its application. The pharmaceutical composition for the treatment of a pathological condition related to diabetes includes: an insulin derivative, which is human insulin A14E, B16H, B25H, B29K ((N^εeicosanedioyl-γGlu-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]acetylamino}ethoxy)ethoxy]acetyl)), desB30; glycerin; phenol; m-cresol; zinc ions; sodium chloride, taken in certain amount and having a pH value of 7.4. The use of a pharmaceutical composition is proposed for the treatment or relief of a disease, disorder or condition selected from a group: disease related to type 1 diabetes, type 2 diabetes, impaired glucose tolerance, hyperglycemia, dyslipidemia, obesity or metabolic syndrome.

EFFECT: above-described invention consists in the development of a new composition with a unique combination of excipients, which allows one to reduce the degree of formation of oligomers at the injection site.

3 cl, 9 dwg, 17 tbl, 8 ex

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RU 2 758 367 C2

Authors

Norrman, Matias

Khostrup, Syuzann

Steensgaard, Dorte, Berre

Shtrauss, Kholger, Martin

Khansen, Roza, Rebekka, Erritsee

Khavelund, Svenn

Sklajn, Morten

Pedersen, Esper, Sennergord

Dates

2021-10-28—Published

2017-12-15—Filed