FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula G, or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein X1, X2, X3, R2, R13, L are defined in the claims, which are JAK inhibitors. Also disclosed are pharmaceutical compositions of the compounds and use thereof in preparing a medicinal agent.
EFFECT: treating and/or preventing a JAK-mediated disease or disorder.
35 cl, 8 dwg, 60 ex
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Year |
Author |
Number |
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2020 |
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| AMINOTRIAZOLOPYRIDINES AND USING THEM AS KINASE INHIBITORS |
2009 |
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RU2552642C2 |
| INHIBITOR OF EGFR AND PRODUCTION AND USE THEREOF |
2015 |
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2002 |
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| PYRAZOLO [3,4-C] PYRIDINES AND METHODS OF APPLICATION THEREOF |
2012 |
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2019 |
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| XIA FACTOR INHIBITORS |
2016 |
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2012 |
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2019 |
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RU2805511C2 |
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2018 |
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