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2 723 599

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IPC

A61K31/282(2006-01-01)

A61K31/519(2006-01-01)

A61K31/505(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2019135147, 2019-10-31

(24)

Start date

2019-10-31

(22)

Actual filing date

2019-10-31

(45)

Published

2020-06-16

(72)

Inventor

Tarasova Anna SergeevnaDobrodeev Aleksej YurevichAfanasev Sergej GennadevichAvgustinovich Aleksandra VladimirovnaVolkov Maksim YurevichDimcha Anastasiya AleksandrovnaUsova Anna VladimirovnaCheremisina Olga Vladimirovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Natsionalnyj Issledovatelskij Meditsinskij Tsentr Rossijskoj Akademii Nauk" Nimts)

METHOD FOR COMBINED TREATMENT OF SUPEROAMPULAR RECTUM CANCER Russian patent published in 2020 - IPC A61K31/282 A61K31/519 A61K31/505 A61P35/00

Abstract RU 2723599 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, and can be used for combined treatment of superoampular rectum cancer. Method involves the preoperative chemotherapy courses in the oxaliplatin/leucovorin/5-fluorouracil regimen, and 3 courses of chemotherapy are performed. Wherein oxaliplatin is administered in dose of 85 mg/m² intravenous drip in 1 day, an infusion duration of 2 hours, leucovorin 200 mg/m² intravenous drip in 1-2 days, infusion duration 2 hours, 5-fluorouracil 400 mg/m² intravenous bolus in 1-2 days, then in dose 600 mg/m² intravenous drip in 1-2 days, infusion duration 22 hours, interval between chemotherapy courses 3 weeks.

EFFECT: using the invention enables improving the results of combined treatment of superoampular rectum cancer by reducing the number of undesirable chemotherapeutic phenomena and reducing the frequency of postoperative complications.

1 cl, 1 ex

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RU 2 723 599 C1

Authors

Tarasova Anna Sergeevna

Dobrodeev Aleksej Yurevich

Afanasev Sergej Gennadevich

Avgustinovich Aleksandra Vladimirovna

Volkov Maksim Yurevich

Dimcha Anastasiya Aleksandrovna

Usova Anna Vladimirovna

Cheremisina Olga Vladimirovna

Dates

2020-06-16—Published

2019-10-31—Filed