PROADM FOR PREDICTING RISK OF CONDITION REQUIRING HOSPITALIZATION IN PATIENTS WITH SYMPTOMS OF INFECTIOUS DISEASE Russian patent published in 2024 - IPC G01N33/68 G01N33/78 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to therapy and infectology, includes a method and a kit which can be used to predict the progression of an infectious disease to a state requiring hospitalization in a patient with symptoms of an infectious disease. Method comprises providing a sample from said patient, determining the level of regional average proadrenomedullin (RA-proADM) in said sample, comparing the RA-proADM level in said sample with a threshold value. Said threshold value is 1.2 nmol/l. RA-proADM level in the above sample is below the specified threshold value indicates that the patient is not exposed to the risk of the infectious disease progression to the state requiring hospitalization. Level of RA-proADM in said sample is higher than said threshold value indicates that the patient is at risk of progression of the infectious disease to a state requiring hospitalization. Kit for implementing the method contains: a) detecting reagents for determining the level of RA-proADM in a sample obtained from a patient, and b) reference data on the risk for the patient as to whether the infectious disease progresses to a condition requiring hospitalization.

EFFECT: group of inventions enables to predict the progression of an infectious disease to a state requiring hospitalization in a patient with symptoms of an infectious disease, by determining the level of RA-proADM in a sample obtained from a patient, and a test system for implementing the method.

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