PROCALCITONIN AND PRO-ADM AS MARKERS FOR MONITORING OF TREATMENT WITH ANTIBIOTICS Russian patent published in 2023 - IPC G01N33/569 G01N33/68 

FIELD: medicine.

SUBSTANCE: present invention relates to a method for control of the treatment with antibiotics in a patient suffering from an infectious disease and receiving treatment with one or more antibiotic agents, including: taking of the first sample in the specified patient, taking of the second sample in the specified patient in a certain period of time after taking of the first sample and after the beginning of the treatment with antibiotics; determination of levels of procalcitonin (hereinafter – PCT) or its fragment(s) in the first and the second samples, and determination of a level of pro-adrenomedullin (hereinafter – proADM) or its fragment(s) in at least the second sample. Moreover, a lower level of PCT or its fragment(s) in the second sample compared to the first sample and a level of high severity of proADM or its fragment(s) in the second sample, or an increased level of severity of proADM or its fragment(s) in the second sample compared to the first sample, including an increase from a level of low severity to a level of moderate or high severity, or from a level of moderate severity to a level of high severity, indicate the necessity of change in one or more antibiotic agents, while the level of low severity of proADM or its fragment(s) is less than 4 nmol/l, the level of moderate severity of proADM or its fragment(s) is more than 4 nmol/l and less than 6.5 nmol/l, and the level of high severity of proADM or its fragment(s) is more than 6.5 nmol/l. In addition, the present invention also relates to a kit for implementation of the method according to the present invention.

EFFECT: invention provides a method and a kit for control of the treatment with antibiotics in a patient suffering from an infectious disease and receiving the treatment with one or more antibiotic agents.

15 cl, 32 tbl