FIELD: medicine.
SUBSTANCE: group of inventions relates to a microneedle system for intradermal delivery of interferon. Disclosed is a soluble matrix of microneedles for intradermal delivery of interferon, obtained from a completely soluble intradermal composition containing interferon as an active principle and the following adjuvants: interferon – 0.1–200 mcg per 1 MNA (one set of microneedles); polyvinylpyrrolidone – 45–95 wt.%; trehalose – 0.1–45 wt.%; polysorbate – 0.001–10 wt.%; glycerine – 0.1–10 wt.%. Also disclosed is a pharmaceutical product and a microneedle system for intradermal delivery of interferon.
EFFECT: group of inventions provides increased stability of interferon in time.
7 cl, 4 dwg, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HEPATITIS VACCINE MICRONEEDLE SYSTEM | 2018 |
|
RU2814278C2 |
| MICRONEEDLE MATRICES WITH UNDERCUT ELEMENTS FOR DERMAL AND NON-DERMAL DRUG DELIVERY | 2020 |
|
RU2816629C2 |
| PHARMACEUTICAL INJECTION TILORONE-BASED COMPOSITION FOR TREATMENT OF DISEASES WITH IMMUNODEFICIENCY SIGNS | 2007 |
|
RU2364390C1 |
| PHARMACEUTICAL INJECTION COMPOSITION ON BASIS OF TILORONE FOR TREATMENT OF PURULENT-DESTRUCTIVE PROCESSES WITH SIGNS OF IMMUNE INSUFFICIENCY | 2007 |
|
RU2359664C1 |
| PHARMACEUTICAL PREPARATION FOR LOCAL AND EXTERNAL APPLICATION BASED ON LOW-MOLECULAR INTERFERON INDUCER | 2007 |
|
RU2351322C1 |
| COMPOSITIONS FOR TREATMENT OF DISSEMINATED SCLEROSIS | 2008 |
|
RU2492234C2 |
| COMPOSITION FOR TREATING MULTIPLE SCLEROSIS (VERSIONS) | 2009 |
|
RU2393861C1 |
| PHARMACEUTICAL PREPARATION FOR LOCAL AND EXTERNAL APPLICATION ON BASIS OF LOW-MOLECULAR INDUCTOR OF INTERFERON | 2007 |
|
RU2352330C1 |
| OPTIMIZED RECOMBINANT PROTEIN ENCODING GENE - HUMAN INTERFERON BETA ANALOG | 2015 |
|
RU2614264C2 |
| MEDICINAL AGENTS WITH CONTROLLED RELEASE BASED ON BLOCK-COPOLYMERS | 2006 |
|
RU2409348C2 |
