HEPATITIS VACCINE MICRONEEDLE SYSTEM Russian patent published in 2024 - IPC A61K39/29 A61K9/00 A61L31/16 A61M37/00 A61P31/20 

Abstract RU 2814278 C2

FIELD: chemistry.

SUBSTANCE: group of inventions relates to a microneedle device containing a composition of polyvinylpyrrolidone and HBsAg, intended for intradermal application for vaccination against hepatitis, where the composition additionally contains trehalose, polysorbate and glycerine, and where content of polyvinylpyrrolidone ranges from 1 to 95% by weight, content of trehalose ranges from 0.1 to 50% by weight, content of polysorbate ranges from 0.01 to 10% by weight, content of glycerine ranges from 0.1 to 10% by weight, also relates to a medical product intended for intradermal administration for hepatitis vaccination, comprising a microneedle device containing a polyvinylpyrrolidone composition and HBsAg, and also relates to a method for intradermal administration for vaccination with HBsAg antigen, characterized by that administration is carried out with a microneedle device containing a composition of polyvinylpyrrolidone and HBsAg.

EFFECT: group of inventions provides a convenient introduction of the hepatitis vaccine without adjuvants, which enables to slightly enhance the vaccination effect due to the introduction of HBsAg through a microneedle device.

9 cl, 1 dwg, 1 tbl

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RU 2 814 278 C2

Authors

Henning, Andreas

Spilgies, Heiko

Dates

2024-02-28Published

2018-11-12Filed