FIELD: medicine; pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely to a method of treating a malignant tumour in a human patient. Method for treating a malignant tumour in a human patient, comprising administering trans-3-amino-1-methyl-3-(4-(3-phenyl-5H-imidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl)cyclobutanol or a salt thereof to a patient in need of treatment, in accordance with the administration schedule, where the introduction regimen includes one course of 7 days, during which trans-3-amino-1-methyl-3-(4-(3-phenyl-5H-imidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl)cyclobutanol or its salt is administered in dose of 4 mg/person/day to 160 mg/person/day in terms of trans-3-amino-1-methyl-3-(4-(3-phenyl-5H-imidazo[1,2-c]pyrido[3,4-e][1,3]oxazine-2-yl)phenyl)cyclobutanol, for 4 consecutive days, followed by a prescribed withdrawal period of 3 days.
EFFECT: use of the invention provides treating a malignant tumour using an imidazooxazine compound having AKT-inhibiting activity with reduced side effects.
14 cl, 4 dwg, 3 tbl, 6 ex
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Authors
Dates
2024-03-26—Published
2020-06-19—Filed