FIELD: biotechnology.
SUBSTANCE: group of inventions relates to biotechnology. Presented are: an antibody molecule containing CH2 and CH3 Fc domains, where the specified CH2 and CH3 Fc domains contain mutations, as well as a method for its preparation and application of this antibody molecule in the manufacture of a drug for the treatment of a disorder in a subject. In addition, a pharmaceutical composition for the treatment of a disorder has been disclosed, where said disorder is associated with an antigen that specifically binds to said antibody molecule, a nucleic acid molecule encoding an antibody molecule, a vector for the expression of an antibody molecule and a cell for producing an antibody molecule. A set for the treatment of a disorder, a method for treating a disorder, where the method includes injecting an effective amount of an antibody molecule to a subject in need, and a method for detecting a molecule specifically bound by an antibody molecule, are also described.
EFFECT: invention is used to treat a disorder in a subject where the specified disorder is associated with an antigen that specifically binds to the specified antibody molecule.
20 cl, 30 dwg, 2 tbl, 16 ex
| Title | Year | Author | Number |
|---|---|---|---|
| Fc OPTIONS WITH INCREASED FcRn BINDING AND PROLONGED HALF-LIFE | 2019 |
|
RU2795592C2 |
| Fc-VERSIONS WITH ALTERED BINDING WITH FcRn | 2008 |
|
RU2517621C2 |
| VARIANTS OF Fc-REGION WITH IMPROVED ABILITY TO BIND TO PROTEIN A | 2015 |
|
RU2698969C2 |
| Fc-VERSIONS WITH CHANGED BINDING WITH FcRn | 2005 |
|
RU2412200C2 |
| POLYPEPTIDE VARIANTS WITH CHANGED EFFECTOR FUNCTION | 2005 |
|
RU2367667C2 |
| IN VITRO PREDICTION OF ANTIBODY HALF-LIFE IN VIVO | 2015 |
|
RU2688349C2 |
| EMBODIMENTS OF Fc-REGION WITH MODIFIED BINDING PROPERTIES OF FcRn AND PROTEIN A | 2015 |
|
RU2713131C1 |
| Fc VERSIONS WITH MODIFIED BINDING WITH FcRn | 2008 |
|
RU2529951C2 |
| VARIANTS OF Fc WITH CHANGED BINDING WITH FcRn | 2014 |
|
RU2700882C2 |
| METHOD FOR SELECTION AND OBTAINING OF HIGHLY SELECTIVE AND MULTISPECIFIC TARGETING GROUPS WITH SPECIFIED PROPERTIES, INCLUDING AT LEAST TWO DIFFERENT BINDING GROUPS, AND THEIR APPLICATIONS | 2013 |
|
RU2639287C2 |
