FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to anti-TNF antibodies, and can be used for their recombinant production. Disclosed is an anti-TNF antibody containing two identical heavy chain polypeptides, each having the amino acid sequence SEQ ID NO: 29; and two identical light chain polypeptides, each having the amino acid sequence SEQ ID NO: 23, as well as means for its recombinant production.
EFFECT: invention provides obtaining anti-TNF antibodies with improved pharmacokinetic properties.
5 cl, 23 dwg, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| Fc VERSIONS WITH MODIFIED BINDING WITH FcRn | 2008 |
|
RU2529951C2 |
| VARIANTS OF Fc WITH CHANGED BINDING WITH FcRn | 2014 |
|
RU2700882C2 |
| Fc-VERSIONS WITH ALTERED BINDING WITH FcRn | 2008 |
|
RU2517621C2 |
| Fc-VERSIONS WITH CHANGED BINDING WITH FcRn | 2005 |
|
RU2412200C2 |
| DESIGNED IL-2-FC FUSION PROTEINS | 2018 |
|
RU2812283C2 |
| VERSIONS OF IMMUNOGLOBULIN AND THEIR APPLICATION | 2009 |
|
RU2536937C2 |
| POLYPEPTIDE VARIANTS WITH CHANGED EFFECTOR FUNCTION | 2005 |
|
RU2367667C2 |
| Fc-RECEPTOR BINDING MODIFIED ASYMMETRIC ANTIBODIES AND METHODS OF USE | 2014 |
|
RU2687043C2 |
| AFFINITY CHROMATOGRAPHY WITH APPLICATION OF Fc-RECEPTORS | 2013 |
|
RU2624128C2 |
| COMPOSITIONS FOR INCREASING HALF-LIFE OF THERAPEUTIC AGENT IN DOGS AND METHODS OF USE THEREOF | 2020 |
|
RU2828219C2 |
