FIELD: biotechnology.
SUBSTANCE: new binding polypeptides applied in medicine. The invention discloses polypeptides with a modified Fc domain in which point mutations have been introduced to increase its ability to bind to FcRn and FcγRIIIa.
EFFECT: polypeptides containing such a modified Fc domain have a prolonged half-life of serum compared to a binding polypeptide containing a wild-type Fc domain.
34 cl, 29 dwg, 10 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| GENETICALLY ENGINEERED POLYPEPTIDES AND USE THEREOF | 2017 |
|
RU2822498C2 |
| METHOD OF CHANGING PLASMA RETENTION AND IMMUNOGENICITY OF ANTIGEN-BINDING MOLECULES | 2012 |
|
RU2799423C1 |
| ANTIBODIES WITH MODIFIED AFFINITY TO FcRn THAT INCREASE ANTIGEN CLEARANCE | 2011 |
|
RU2745989C2 |
| VARIANTS OF Fc-DOMAIN WITH MODIFIED FcRn BINDING AND METHODS OF APPLICATION THEREOF | 2015 |
|
RU2714116C2 |
| Fc-VERSIONS WITH ALTERED BINDING WITH FcRn | 2008 |
|
RU2517621C2 |
| VERSIONS OF IMMUNOGLOBULIN AND THEIR APPLICATION | 2009 |
|
RU2536937C2 |
| AFFINITY CHROMATOGRAPHY WITH APPLICATION OF Fc-RECEPTORS | 2013 |
|
RU2624128C2 |
| HYPERGLYCOSYLATED BINDING POLYPEPTIDES | 2014 |
|
RU2708314C2 |
| EMBODIMENTS OF Fc-REGION WITH MODIFIED BINDING PROPERTIES OF FcRn AND PROTEIN A | 2015 |
|
RU2713131C1 |
| SITE-SPECIFIC ANTIBODY-DRUG CONJUGATION BY MEANS OF GLYCOENGINEERING | 2014 |
|
RU2711935C2 |
