FIELD: biotechnology.
SUBSTANCE: invention relates to immunology and biotechnology. Disclosed is a recombinant C5 antibody comprising a variant Fc of a native wild type Fc IgG1 polypeptide, wherein said version includes 428L/434S/259I, and numbering is given according to EU index. Described are a coding nucleic acid, an expression vector and a host cell for antibody expression based on said vector. Also described is a method for producing the antibody by culturing said cell.
EFFECT: use of the invention provides higher binding of mouse or human to FcRn, as compared to native Fc IgG1 polypeptide, which can find application in medicine.
6 cl, 23 dwg, 7 ex
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