COMPOUNDS OF FORMULA (I) AND FORMULA (A), PHARMACEUTICAL COMPOSITION, MEDICINAL PRODUCT, USE AND METHOD OF OBTAINING COMPOUNDS OF FORMULA (I) Russian patent published in 2024 - IPC C07D497/14 A61K31/519 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (Ia) or a pharmaceutically acceptable salt thereof, where R¹ represents a 5-membered heteroaryl; preferably R¹ is furyl; X¹ and X² are each independently C or N; R^1' is absent when X¹ is N; or, when X¹ is C, R^1' is H, halogen, alkyl, heterocyclyl, alkoxy, heterocyclyloxy, aminocarbonyl, hydroxycarbonyl, heterocyclylcarbonyl, alkylsulfoxide, alkylsulfonyl, aminosulfonyl, heterocyclylsulfonyl or alkylsulfonimidoyl; wherein the said substituents are optionally substituted with one to four substituents selected from oxo, halogen, hydroxy, alkyl, heterocyclylalkyl, hydroxyalkyl, dihydroxyalkyl, hydroxyalkylaminoalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, (heterocyclyl)(alkyl)aminoalkyl, heterocyclyl, heteroaryl, alkylheteroaryl, amino, dialkylamino, aminoalkylcarbonylamino, aminocarbonylalkylamino, (aminocarbonylalkyl)(alkyl)amino, hydroxycarbonyl, aminocarbonyl, aminoalkylaminocarbonyl, alkylaminoalkylaminocarbonyl, dialkylaminoalkylaminocarbonyl, heterocyclylalkylaminocarbonyl, (alkylaminoalkyl)(alkyl) aminocarbonyl, heterocyclylcarbonyl, alkyl sulfoxide, alkyl sulfoxide alkyl and alkyl sulfonyl; R^2' is H, alkyl, heterocyclyl, alkoxy, heterocyclyloxy, aminocarbonyl, heterocyclylcarbonyl or alkyl sulfoxide; wherein said substituents are optionally substituted with one or two substituents selected from oxo, halogen, hydroxy, cyano, alkyl, heterocyclylalkyl, dihydroxyalkyl, dialkylaminoalkyl, heterocyclyl, heteroaryl, alkylheteroaryl, hydroxycarbonyl, alkyloxycarbonyl, aminocarbonyl, alkylaminoalkylaminocarbonyl, dialkylaminoalkylaminocar bonyl, heterocyclylalkylaminocarbonyl, alkylsulfoxide, alkylsulfoxidealkyl and alkylsulfonyl; or R^1' and R^2' form, together with the atoms to which they are attached, a 5-membered heterocyclyl ring; substituted oxo; R^3' is absent when X² is N; or, when X² represents C, R^3' represents H or halogen, preferably H or F; R^4' represents H or halogen, preferably H or F; and R^5' is H; and where the alkyl group, as such or part of another substituent, contains from 1 to 4 carbon atoms; the heterocyclyl group, as such or part of another substituent, contains from 4 to 6 ring atoms and includes 1 or 2 heteroatoms selected from N, O and/or S; and the heteroaryl group, as such or part of another substituent, contains 5 ring atoms and includes from 1 to 4 heteroatoms selected from N and/or O. The invention also relates to a pharmaceutical composition and drug inhibiting the A2A type adenosine receptor based on the above compounds, method of their preparation and intermediate compounds for their preparation.

EFFECT: obtaining new compounds and a pharmaceutical composition based on them which can be used in medicine in the treatment and prevention of cancer.

20 cl, 4 dwg, 10 tbl, 132 ex