FIELD: chemistry.
SUBSTANCE: group of inventions relates to organic chemistry and includes a compound of formula I or pharmaceutically acceptable salts thereof, individual compounds specified in the claim, or their pharmaceutically acceptable salts, a pharmaceutical composition based thereon and use. In the formula, IR1 is selected from a group consisting of C1-C6 alkyl, CF3, CH2CF3, CF2CHF2, C3-C8 cycloalkyl, where said C3-C8 cycloalkyl can be substituted with 1 or 2 substituents selected from the group consisting of C1-C3 alkyl, F, CHF2 and CF3; R2 represents H, C1-C6 alkyl or CF3; or R1 and R2 are combined to form C3-C5 cycloalkyl, optionally substituted with 1 or 2 F, CHF2 or CF3; R3 is CH2-O-cyclopropyl, C1-C3 alkyl or CH2O-C1-3 alkyl, wherein said C1-C3 alkyl or CH2O-C1-C3 alkyl substituted with C≡N, 3 F or C3-C5 cycloalkyl, R4 is selected from the group consisting of OCF3 or OCHF2.
EFFECT: compounds defined in the claims for treating disorders responsive to Kv7 potassium channel activation.
12 cl, 35 ex
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