IMMUNE CELLS EXPRESSING INVERSE UNIVERSAL CHIMERIC ANTIGEN RECEPTOR, FOR TARGETING VARIOUS MULTIPLE ANTIGENS AND METHOD FOR PRODUCTION AND USE THEREOF FOR TREATING CANCER, INFECTIONS AND AUTOIMMUNE DISEASES Russian patent published in 2024 - IPC C07K14/725 C07K14/705 C07K16/28 A61K39/00 

FIELD: biotechnology; medicine.

SUBSTANCE: disclosed is a nucleic acid coding a reverse universal chimeric antigen receptor (RevCAR), where the receptor contains three domains, wherein the first domain is a peptide epitope label, the second domain is a binding peptide chain and the third domain is a signal transduction domain, where the peptide epitope label serving as a binding domain with the cell surface is a linear or conformational epitope. Also disclosed is an adapter module consisting of a binding fragment specific for a certain protein or protein complex on the surface of a human cell, and a binding fragment specific for a peptide epitope label as a domain that binds RevCAR to a cell surface.

EFFECT: invention provides a reverse universal modular system RevCAR, which provides retargeting RevCAR-grafted immune cells against multiple antigens.

19 cl, 9 dwg