CHIMERIC ANTIGENE RECEPTORS TARGETTING FLT3 Russian patent published in 2024 - IPC C07K14/705 C07K16/30 A61K35/17 C07K19/00 C12N15/62 C12N15/63 C12N5/10 A61P35/02 

Abstract RU 2820859 C2

FIELD: immunotherapy.

SUBSTANCE: group of inventions relates to immunotherapy targeting FLT3. The following is disclosed: chimeric antigen receptors (CARs) that specifically bind to FLT3, polynucleotides encoding FLT3 CARs, engineered immune cells containing FLT3-specific CARs, methods of engineering immune cells to express FLT3-specific CARs, and methods of using T-cells with FLT3-specific CARs for the treatment of malignant neoplasms accompanied by impaired FLT3 expression.

EFFECT: obtaining chimeric antigene receptors targeting FLT3.

77 cl, 7 dwg, 3 ex

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RU 2 820 859 C2

Authors

Sasu, Barbra Johnson

Dettling, Danielle Elizabeth

Sommer, Cesar Adolfo

Yeung, Yik Andy

Hamze, Moustafa Marc

Dates

2024-06-11Published

2018-05-31Filed